Niclosamide yog ib qho bioavailable chlorinated salicylanilide, nrog anthelmintic thiab muaj peev xwm ua haujlwm antineoplastic. Raws li kev tswj hwm qhov ncauj, niclosamide tshwj xeeb ua rau muaj kev puas tsuaj ntawm androgen receptor (AR) variant V7 (AR-V7) los ntawm txoj kev proteasome-mediated. Qhov no txo ​​qis kev qhia ntawm AR variant, inhibits AR-V7-mediated transcriptional kev ua, thiab txo AR-V7 recruitment rau prostate-specific antigen (PSA) gene prostate. Niclosamide tseem tiv thaiv AR-V7-mediated STAT3 phosphorylation thiab ua kom muaj zog. Qhov no inhibits AR / STAT3-mediated signaling thiab tiv thaiv kev qhia ntawm STAT3 hom phiaj noob. Ua ke, qhov no tuaj yeem cuam tshuam kev loj hlob ntawm AR-V7-overexpressing qog noj ntshav. AR-V7 variant, uas yog encoded los ntawm kev sib txuas sib txuas ntawm AR exons 1/2/3/CE3, yog upregulated nyob rau hauv ntau hom mob qog noj ntshav, thiab muaj feem xyuam nrog ob qho tib si mob qog noj ntshav thiab tiv thaiv AR-targeted kev kho mob.

Kev sib xyaw:

Txhua bolus cotnains 1250 mg niclosamide

Kev taw qhia:

Rau ruminants kab mob paramphistomes, cestodiasis, xws li nyuj thiab yaj's moniezia, avitellina centripunctata, thiab lwm yam.

Dosage thiab siv:

Hais lus txhua 1 kg lub cev hnyav.

Yog ': 40-60 mg

yaj: 60-70mg

Lub sijhawm rho nyiaj:

Yaj: 28 hnub.

nyuj: 28 hnub.

Pob loj: 5 ntsiav tshuaj ib lub hlwv, 10 hlwv rau ib lub thawv