Nicolsamide ntsiav tshuaj
Niclosamide yog ib qho bioavailable chlorinated salicylanilide, nrog anthelmintic thiab muaj peev xwm ua haujlwm antineoplastic.Raws li kev tswj hwm qhov ncauj, niclosamide tshwj xeeb ua rau muaj kev puas tsuaj ntawm androgen receptor (AR) variant V7 (AR-V7) los ntawm txoj kev proteasome-mediated.Qhov no txo qis kev qhia ntawm AR variant, inhibits AR-V7-mediated transcriptional activation, thiab txo AR-V7 recruitment rau prostate-specific antigen (PSA) gene prostate.Niclosamide tseem tiv thaiv AR-V7-mediated STAT3 phosphorylation thiab ua kom muaj zog.Qhov no inhibits AR / STAT3-mediated signaling thiab tiv thaiv kev qhia ntawm STAT3 hom phiaj noob.Ua ke, qhov no tuaj yeem cuam tshuam kev loj hlob ntawm AR-V7-overexpressing cancer hlwb.AR-V7 variant, uas yog encoded los ntawm contiguous splicing ntawm AR exons 1/2/3 / CE3, yog upregulated nyob rau hauv ntau yam mob qog noj ntshav hom, thiab yog txuam nrog rau ob qho tib si mob qog noj ntshav thiab tsis kam mus rau AR-targeted kev kho mob.
Kev sib xyaw:
Txhua bolus cotnains 1250 mg niclosamide
Kev taw qhia:
Rau ruminants kab mob paramphistomes, cestodiasis, xws li nyuj thiab yaj's moniezia, avitellina centripunctata, thiab lwm yam.
Dosage thiab siv:
Hais lus txhua 1 kg lub cev hnyav.
Yog ': 40-60 mg
yaj: 60-70mg
Lub sijhawm rho nyiaj:
Yaj: 28 hnub.
nyuj: 28 hnub.
Pob loj: 5 ntsiav tshuaj ib lub hlwv, 10 hlwv rau ib lub thawv
